Biography

Prof. Kenneth Lo obtained his BSc (1993) and PhD (1997) degrees at The University of Hong Kong.  His PhD work centered on the design of luminescent transition metal complexes as DNA and metal-ion probes; and the photophysical and photochemical studies of luminescent polynuclear coinage metal chalcogenide complexes.  From 1997 to 1999, he worked as a Croucher Foundation Postdoctoral Research Fellow in the research groups of Prof. H. Allen O. Hill, FRS and Dr. Luet-Lok Wong of the Inorganic Chemistry Laboratory, University of Oxford.  He carried out research work on genetic engineering and electrochemistry of cytochrome P450cam and putidaredoxin.  Prof. Lo joined the Department of Biology and Chemistry (currently Department of Chemistry) of City University of Hong Kong as Assistant Professor in 1999 and became Associate Professor (Scale B) in 2003, Associate Professor (Scale A) in 2007, Professor in 2011, and Chair Professor in 2023.  He is currently the Program Leader of BSc (Hons) Chemistry.  At the College level, he is a member of the College Board.  At the University level, he is the Director of the Talent and Education Development Office.

Prof. Lo's research interest is the utilization of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes, with a focus on the development of intracellular sensors, photoactive labels, and bioimaging reagents.  He received The APA Prize for Young Scientist from The Asian and Oceanian Photochemistry Association in 2005 and The Distinguished Lectureship Award from The Chemical Society of Japan in 2011.  He was awarded a Croucher Senior Research Fellowship from the Croucher Foundation in 2015 and was admitted as a Fellow of the Royal Society of Chemistry (FRSC) in 2018.  He also received the CityU College of Science Inaugural Teaching Excellence Award (2021 – 2022) and the CityU Teaching Excellence Award (2022 – 2023).  He was one of the Chairs of the Gordon Research Conference Metals in Medicine 2018 and is the Chair of the 23rd International Symposium of the Photochemistry and Photophysics of Coordination Compounds (ISPPCC 2019).  He was on the Editorial Advisory Board of Inorganic Chemistry (2015 – 2017) and the Advisory Board of RSC Advances (2013 – 2015).  He served as an Associate Editor for RSC Advances (2015 – 2020) and has been an Associate Editor for Inorganic Chemistry since 2020.




Publications

173.   G.-X. Xu, L. C.-C. Lee, P. K.-K. Leung, E. C.-L. Mak, J. Shum, K. Y. Zhang, Q. Zhao and K. K.-W. Lo, "Bioorthogonal Dissociative Rhenium(I) Photosensitisers for Controlled Immunogenic Cell Death Induction", Chemical Science, 2023, in press ( Link ).
172.   R. Zhu, P. Dai, J. Yang, J. Zhou, J. Zhang, K. Y. Zhang, Y. Li, S. Liu, K. K.-W. Lo and Q. Zhao, "Dual-emissive Iridium(III) Complexes as Phosphorescent Probes with Orthogonal Responses to Analyte Binding and Oxygen Quenching", Angewandte Chemie International Edition, 2023, e202309178 ( Link ).
171.   S. Dehnen, J. W. Steed, K. Lo, K. Heinze, O. S. Wenger, S. Singh, H.-B. Yang and S.-Q. Zang, "We Glow Together: A Dialogue on Luminescent Compounds", Inorganic Chemistry, 2023, 62, 14823 – 14827 ( Link ); Crystal Growth & Design, 2023, 23, 6993 – 6997 ( Link ) (A joint virtual issue).
170.   L. Hua, K. Y. Zhang, H.-W. Liu, K. S. Chan and K. K.-W. Lo, "Luminescent Iridium(III) Porphyrin Complexes as Near-Infrared-Emissive Biological Probes", Dalton Transactions, 2023, 52, 12444 – 12453 ( Link ).
169.   J. Shum, L. C.-C. Lee, M. W.-L. Chiang, Y.-W. Lam and K. K.-W. Lo, "A Concerted Enzymatic and Bioorthogonal Approach for Extracellular and Intracellular Activation of Environment-Sensitive Ruthenium(II)-Based Imaging Probes and Photosensitizers", Angewandte Chemie International Edition, 2023, e202303931 ( Link ).
168.   K. K.-W. Lo, "Inorganic Chemistry in Hong Kong", European Journal of Inorganic Chemistry, 2023, 26, e202200702 ( Link ).
167.   L. C.-C. Lee and K. K.-W. Lo, "Luminescence Chemosensors, Biological Probes, and Imaging Reagents", Comprehensive Inorganic Chemistry III, 2023, 152 – 253 ( Link ).
166.   L. C.-C. Lee and K. K.-W. Lo, "Strategic Design of Photofunctional Transition Metal Complexes for Cancer Diagnosis and Therapy", Advances in Inorganic Chemistry, 2022, 80, 35 – 94 ( Link ).
165.   L. C.-C. Lee, L. Huang, P. K.-K. Leung and K. K.-W. Lo, "Recent Development of Photofunctional Transition Metal–Peptide Conjugates for Bioimaging and Therapeutic Applications", European Journal of Inorganic Chemistry, 2022, e202200455 ( Link ) (included in the Institute Feature that highlights the inorganic chemistry in the universities in Hong Kong). Cover Picture for Issue 35/2022 ( Link ).
164.   L. C.-C. Lee and K. K.-W. Lo, "Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing", Chemistry – An Asian Journal, 2022, e202200840 ( Link ).
163.   L. Huang, P. K.-K. Leung, L. C.-C. Lee, G.-X. Xu, Y.-W. Lam and K. K.-W. Lo, "Photofunctional Cyclometallated Iridium(III) Polypyridine Methylsulfone Complexes as Sulfhydryl-specific Reagents for Bioconjugation, Bioimaging and Photocytotoxic Applications", Chemical Communications, 2022, 58, 10162 – 10165 ( Link ) (an invited article included in the Themed Collection entitled “Celebrating 10 years of Chemical Communications Emerging Investigators”).
162.   L. C.-C. Lee and K. K.-W. Lo, "Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications", Journal of the American Chemical Society, 2022, 144, 14420 – 14440 ( Link ).
161.   J. Wang, Y. Jin, M. Li, S. Liu, K. K.-W. Lo and Q. Zhao, "Time-Resolved Luminescent Sensing and Imaging for Enzyme Catalytic Activity Based on Responsive Probes", Chemistry – An Asian Journal, 2022, 17, e202200429 ( Link ).
160.   A. M.-H. Yip, C. K.-H. Lai, K. S.-M. Yiu and K. K.-W. Lo, "Phosphorogenic Iridium(III) bis-Tetrazine Complexes for Bioorthogonal Peptide Stapling, Bioimaging, Photocytotoxic Applications, and the Construction of Nanosized Hydrogels", Angewandte Chemie International Edition, 2022, 61, e202116078 ( Link ).
159.   A. J. Carrod, F. Graglia, L. Male, C. Le Duff, P. Simpson, M. Elsherif, Z. Ahmed, H. Butt, G.-X. Xu, K. K.-W. Lo, P. Bertoncello and Z. Pikramenou, "Photo- and Electrochemical Dual-responsive Iridium Probe for Saccharide Detection", Chemistry – A European Journal, 2022, 28, e202103541 ( Link ).
158.   J.-H. Zhu, G.-X. Xu, J. Shum, L. C.-C. Lee and K. K.-W. Lo, "Tuning the Organelle Specificity and Cytotoxicity of Iridium(III) Photosensitizers for Enhanced Phototheranostic Applications", Chemical Communications, 2021, 57, 12008 – 12011 ( Link ).
157.   P. K.-K. Leung, L. C.-C. Lee, T. K.-Y. Ip, H.-W. Liu, S.-M. Yiu, N. P. Lee and K. K.-W. Lo, "Luminescent Rhenium(I) Perfluorobiphenyl Complexes as Site-specific Labels for Peptides to Afford Photofunctional Bioconjugates", Chemical Communications, 2021, 57, 11256 – 11259 ( Link ).
156.   G.-X. Xu, E. C.-L. Mak and K. K.-W. Lo, "Photofunctional Transition Metal Complexes as Cellular Probes, Bioimaging Reagents and Phototherapeutics", Inorganic Chemistry Frontiers, 2021, 8, 4553 – 4579 ( Link ).
155.   G.-X. Xu, L. C.-C. Lee, C. W.-C. Kwok, P. K.-K. Leung, J.-H. Zhu and K. K.-W. Lo, "Utilization of Rhenium(I) Polypyridine Complexes Featuring a Dinitrophenylsulfonamide Moiety as Biothiol-Selective Phosphorogenic Bioimaging Reagents and Photocytotoxic Agents", European Journal of Inorganic Chemistry, 2021, 3432 – 3442 ( Link ). Cover Picture for Issue 34/2021 ( Link ).
154.   J.-H. Zhu, S.-M. Yiu, B. Z. Tang and K. K.-W. Lo, "Luminescent Neutral Cyclometalated Iridium(III) Complexes Featuring a Cubic Polyhedral Oligomeric Silsesquioxane for Lipid Droplet Imaging and Photocytotoxic Applications", Inorganic Chemistry, 2021, 60, 11672 – 11683 ( Link ).
153.   H. I. Kremer, K. W. Leung, W. C. Wong, K. K.-W. Lo and M. W. K. Lee, "Design of Dielectric Resonator Antenna Using Dielectric Paste", Sensors, 2021, 21, 4058 ( Link ).
152.   P. K.-K. Leung, L. C.-C. Lee, H. H.-Y. Yeung, K. W. Io and K. K.-W. Lo, "Bioorthogonal Control of the Phosphorescence and Singlet Oxygen Photosensitisation Properties of Iridium(III) Tetrazine Complexes", Chemical Communications, 2021, 57, 4914 – 4917 ( Link ).
151.   K. K.-W. Lo, "Preface: The 23rd International Symposium on the Photochemistry and Photophysics of Coordination Compounds (ISPPCC 2019)", Coordination Chemistry Reviews, 2021, 434, 213800 ( Link ).
150.   A. S.-Y. Law, L. C.-C. Lee, K. K.-W. Lo and V. W.-W. Yam, "Aggregation and Supramolecular Self-Assembly of Low-Energy Red Luminescent Alkynylplatinum(II) Complexes for RNA Detection, Nucleolus Imaging, and RNA Synthesis Inhibitor Screening", Journal of the American Chemical Society, 2021, 143, 5396 – 5405 ( Link ).

149.   L. C.-C. Lee, A. W.-Y. Tsang, H.-W. Liu and K. K.-W. Lo, "Photofunctional Cyclometalated Iridium(III) Polypyridine Complexes Bearing a Perfluorobiphenyl Moiety for Bioconjugation, Bioimaging, and Phototherapeutic Applications", Inorganic Chemistry, 2020, 59, 14796 – 14806 ( Link ).
148.   P. K.-K.- Leung and K. K.-W. Lo, "Modulation of emission and singlet oxygen photosensitisation in live cells utilising bioorthogonal phosphorogenic probes and protein tag technology", Chemical Communications, 2020, 56, 6074 – 6077 ( Link ).
147.   K. K.-W. Lo, "Preface: The 23rd International Symposium on the Photochemistry and Photophysics of Coordination Compounds (ISPPCC 2019)", Journal of Inorganic Biochemistry, 2020, 209, 111128 ( Link ).
146.   J. Shum, P.-Z. Zhang, L. C.-C. Lee and K. K.-W. Lo, "Bioorthogonal Phosphorogenic Rhenium(I) Polypyridine Sydnone Complexes for Specific Lysosome Labeling", ChemPlusChem, 2020, 85, 1374 – 1378 ( Link ). Cover Picture for Issue 7/2020 ( Link ).
145.   K. K.-W. Lo, "Molecular Design of Bioorthogonal Probes and Imaging Reagents Derived from Photofunctional Transition Metal Complexes", Accounts of Chemical Research, 2020, 53, 32 – 44 ( Link ).
144.   A. S.-Y. Law, L. C.-C. Lee, M. C.-L. Yeung, K. K.-W. Lo and V. W.-W. Yam, "Amyloid Protein-Induced Supramolecular Self-Assembly of Water-Soluble Platinum (II) Complexes: A Luminescence Assay for Amyloid Fibrillation Detection and Inhibitor Screening", Journal of the American Chemical Society, 2019, 141, 18570 – 18577 ( Link ).
143.   J.-H. Zhu, B. Z. Tang, and K. K.-W. Lo, "Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake and Bioimaging Studies", Chemistry – A European Journal, 2019, 25, 10633 – 10641 ( Link ).
142.   S. P.-Y. Li, V. M.-W. Yim, J. Shum and K. K.-W. Lo, "Iridium(III) Polypyridine Complexes with a Disulfide Linker as Biological Sensors and Cytotoxic Agents", Dalton Transactions, 2019, 48, 9692 – 9702 ( Link ) (under the theme "Diagnostics and Medical Applications" of the themed issue "d-Block Chemistry").
141.   A. M.-H. Yip, J. Shum, H.-W. Liu, H. Zhou, M. Jia, N. Niu, Y. Li, C. Yu and K. K.-W. Lo, "Luminescent Rhenium(I) Polypyridine Complexes Appended with a Perylene Diimide or Benzoperylene Monoimide Moiety: Photophysics, Intracellular Sensing, and Photocytotoxic Activity", Chemistry – A European Journal, 2019, 25, 8970 – 8974 ( Link ).
140.   J. Shum, P. K.-K. Leung and K. K.-W. Lo "Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications", Inorganic Chemistry, 2019, 58, 2231 – 2247 ( Link ).
139.   L. C.-C. Lee, H. M.-H. Cheung, H.-W. Liu and K. K.-W. Lo, "Exploitation of Environment-sensitive Luminophores in the Design of Novel Sydnone-based Bioorthogonal Imaging Reagents", Chemistry – A European Journal, 2018, 24, 14064 – 14068 ( Link ).
138.   K. Y. Zhang, P. Gao, G. Sun, T. Zhang, X. Li, S. Liu, Q. Zhao, K. K.-W. Lo, and W. Huang, "Dual-phosphorescent Iridium(III) Complexes Extending Oxygen Sensing from Hypoxia to Hyperoxia", Journal of the American Chemical Society, 2018, 140, 7827 – 7834 ( Link ).
137.   A. M.-H. Yip and K. K.-W. Lo "Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Polypyridine Complexes Containing a Poly(ethylene glycol) Pendant or Bioorthogonal Reaction Group as Biological Probes and Photocytotoxic Agents", Coordination Chemistry Reviews, 2018, 361, 138 – 163 ( Link ).
136.   L. C.-C. Lee, K.-K. Leung and K. K.-W. Lo, "Recent Development of Luminescent Rhenium(I) Tricarbonyl Polypyridine Complexes as Cellular Imaging Reagents, Anticancer Drugs, and Antibacterial Agents", Daltons Transactions, 2017, 46, 16357 – 16380 ( Link ).
135.   C. T.-S. Lau, C. Chan, K. Y. Zhang, V. A. L. Roy and K. K.-W. Lo, "Photophysical, Cellular Uptake, and Bioimaging Studies of Luminescent Ruthenium(II) Polypyridine Complexes Containing a D-Fructose Pendant", European Journal of Inorganic Chemistry, 2017, 5288 – 5294 ( Link ).
134.   K. K.-W. Lo and L. J. Charbonnière, "Luminescent Materials: Metal Complexes, Clusters, and Nanomaterials", European Journal of Inorganic Chemistry, 2017, 5055 – 5057 ( Link ).
133.   K. K.-S. Tso, H.-W. Liu and K. K.-W. Lo, "Phosphorogenic Sensors for Biothiols Derived from Cyclometalated Iridium(III) Polypyridine Complexes Containing a Dinitrophenyl Ether Moiety", Journal of Inorganic Biochemistry, 2017, 177, 412 – 422 ( Link ).
132.   Y. Li, S. Yin, Y. Lu, H. Zhou, H. Jiang, N. Niu, H. Huang, L. Zhang, K. K.-W. Lo and C. Yu, "Choline Sensing Based on In Situ Polymerization of Aniline on the Surface of Upconverting Nanoparticles", Journal of Materials Chemistry B, 2017, 5, 7861 – 7865 ( Link ).
131.   X. Huang, S. A. Shahzad, Y. Li, Y. Zhang, H. Zhou, H. Jiang, K. K.-W. Lo and C. Yu. "Silver nanoclusters capped silica nanoparticles as a ratiometric photoluminescence nanosensor for the selective detection of I– and S2–", Analytical Chimica Acta, 2017, 988, 74 – 80 ( Link ).
130.   X. Y. Zhang, Y. Li, C. Zhang, Q. Zhang, X. Huang, M. Yang, S. A. Shahzad, K. K.-W. Lo and C. Yu and S. Jiang, "Fluorescence Turn-on Detection of Alkaline Phosphatase Activity Based on Controlled Release of PEI-capped Cu Nanoclusters from MnO2 Nanosheets", Analytical and Bioanalytical Chemistry, 2017, 409, 4771 – 4778 ( Link ).
129.   H.-W. Liu, W. H.-T. Law, L. C.-C. Lee, J. C.-W. Lau and K. K.-W. Lo, “Cyclometalated Iridium(III) Bipyridine-Phenylboronic Acid Complexes as Luminescent Probes for Sialic Acids and Bioimaging Reagents”, Chemistry – An Asian Journal, 2017, 12, 1545 – 1556 ( Link ).
128.   T. S.-M. Tang, H.-W. Liu and K. K.-W. Lo, "Monochromophoric Iridium(III) Pyridyl-tetrazine Complexes as a Unique Design Strategy for Bioorthogonal Probes with Luminogenic Behavior", Chemical Communications, 2017, 53, 3299 – 3302 ( Link ). Cover Picture for Issue 23 ( Link ).
127.   S. P.-Y. Li, A. M.-H. Yip, H.-W. Liu and K. K.-W. Lo, “Installing an Additional Emission Quenching Pathway in the Design of Iridium(III)-based Phosphorogenic Biomaterials for Bioorthogonal Labeling and Imaging", Biomaterials, 2016, 103, 305 – 313 ( Link ).
126.   T. S.-M. Tang, H.-W. Liu and K. K.-W. Lo, “Structural Manipulation of Ruthenium(II) Polypyridine Nitrone Complexes to Generate Phosphorogenic Bioorthogonal Reagents for Selective Cellular Labelling”, Chemistry – A European Journal, 2016, 9649 – 9659 ( Link ).
125.   K. K.-S. Tso, K.-K. Leung, H.-W. Liu and K. K.-W. Lo, “Photoactivatable Cytotoxic Agents Derived from Mitochondria-targeting Luminescent Iridium(III) Poly(ethylene glycol) Complexes Modified with a Nitrobenzyl Linkage”, Chemical Communications, 2016, 52, 4557 – 4560 ( Link ).
124.   L. C.-C. Lee, J. C.-W. Lau, H.-W. Liu and K. K.-W. Lo, “Conferring Phosphorogenic Properties on Iridium(III)-based Bioorthogonal Probes through the Modification with a Nitrone Unit", Angewandte Chemie International Edition, 2016, 55, 1046 – 1049 ( Link ).
123.   K. K.-W. Lo, "Luminescent Iridium(III) and Rhenium(I) Complexes as Biomolecular Probes and Imaging Reagents", Advances in Inorganic Chemistry, 2016, 68, 97 – 140 ( Link ).

122.   K. K.-W. Lo, "Luminescent Rhenium(I) and Iridium(III) Polypyridine Complexes as Biological Probes, Imaging Reagents, and Photocytotoxic Agents", Accounts of Chemical Research, 2015, 48, 2985 – 2995 ( Link ). Cover Picture for Issue 12 ( Link ).
121.   T. S.-M. Tang, A. M.-H. Yip, K. Y. Zhang, H.-W. Liu, P. L. Wu, K. F. Liu, K. W. Cheah and K. K.-W. Lo, “Bioorthogonal Labeling, Bioimaging, and Photocytotoxicity Studies of Phosphorescent Ruthenium(II) Polypyridine Dibenzocyclooctyne Complexes”, Chemistry – A European Journal, 2015, 21, 10729 – 10740 ( Link ).
120.   K. Y. Zhang, H.-W. Liu, M.-C. Tang, A. W.-T. Choi, N. Zhu, X.-G. Wei, K.-C. Lau and K. K.-W. Lo, "Dual-Emissive Cyclometalated Iridium(III) Polypyridine Complexes as Ratiometric Biological Probes and Organelle-Selective Bioimaging Reagents", Inorganic Chemistry, 2015, 54, 6582 – 6593 ( Link ).
119.   K. K.-W. Lo and K. K.-S. Tso, “Functionalization of Cyclometalated Iridium(III) Polypyridine Complexes for the Design of Intracellular Sensors, Organelle-targeting Imaging Reagents, and Metallodrugs”, Inorganic Chemistry Frontiers, 2015, 2, 510 – 524 ( Link ).
118.   A. W.-T. Choi, H.-W. Liu and K. K.-W. Lo, “Rhenium(I) Polypyridine Dibenzocyclooctyne Complexes as Phosphorescent Bioorthogonal Probes: Synthesis, Characterization, Emissive Behavior, and Biolabeling Properties”, Journal of Inorganic Biochemistry, 2015, 148, 2 – 10 ( Link ). The 12th European Biological Inorganic Chemistry Conference (EuroBIC 12) ( Link ).
117.   A. W.-T. Choi, K. K.-S. Tso, V. M.-W. Yim, H.-W. Liu and K. K.-W. Lo, “Modification of 1,2,4,5-Tetrazine with Cationic Rhenium(I) Polypyridine Units to Afford Phosphorogenic Bioorthogonal Probes with Enhanced Reaction Kinetics”, Chemical Communications, 2015, 51, 3442 – 3445 ( Link ).
116.   K. K.-W. Lo, T. S.-M. Tang, K.-K. Leung, M.-W. Louie, H.-W. Liu and S. H. Cheng, “Phosphorescent Biscyclometalated Iridium(III) Ethylenediamine Complexes Functionalized with Polar Ester or Carboxylate Groups as Bioimaging and Visualization Reagents”, Dalton Transactions, 2015, 44, 4945 – 4956 ( Link ). Dalton Discussion 15: Metal Ions in Medical Imaging: Optical, Radiopharmaceutical and MRT Contrast.
115.   A. W.-T. Choi, V. M.-W. Yim, H.-W. Liu and K. K.-W. Lo, “Rhenium(I) Polypyridine Diamine Complexes as Intracellular Phosphorogenic Sensors: Synthesis, Characterization, Emissive Behavior, Biological Properties, and Nitric Oxide Sensing”, Chemistry – A European Journal, 2014, 20, 9633 – 9642 ( Link ).
114.   W. H.-T. Law, K.-K. Leung, L. C.-C. Lee, C.-S. Poon, H.-W. Liu and K. K.-W. Lo, “Cyclometalated Iridium(III) Bipyridyl–Phenylenediamine Complexes with Multicolor Phosphorescence: Synthesis, Electrochemistry, Photophysics, and Intracellular Nitric Oxide Sensing”, ChemMedChem, 2014, 9, 1316 – 1329 ( Link ).
113.   K. Y. Zhang and K. K.-W. Lo, Metal Complexes for Cell and Organism Imaging. In Inorganic Chemical Biology: Principles, Techniques and Applications; G. Gasser Ed.; John Wiley & Sons: UK, 2014, pp 99 – 148 ( Link ).
112.   J. Liu, K.-K. Yee, K. K.-W. Lo, K. Y. Zhang, W.-P. To, C.-M. Che and Z. Xu, “Selective Ag(I) Binding, H2S Sensing, and White-Light Emission from an Easy-to-Make Porous Conjugated Polymer”, Journal of the American Chemical Society, 2014, 136, 2818 – 2824 ( Link ).
111.   S. P.-Y. Li and K. K.-W. Lo, “Utilization of the Photophysical and Photochemical Properties of Phosphorescent Transition Metal Complexes in the Development of Photofunctional Cellular Sensors, Imaging Reagents, and Cytotoxic Agents”, RSC Advances, 2014, 4, 10560 – 10585 ( Link ).
110.   W. H.-T. Law, L. C.-C. Lee, M.-W. Louie, H.-W. Liu, T. W.-H. Ang and K. K.-W. Lo, "Phosphorescent Cellular Probes and Uptake Indicators Derived from Cyclometalated Iridium(III) Bipyridine Complexes Appended with a Glucose or Galactose Entity", Inorganic Chemistry, 2013, 52, 10329 – 13041 ( Link ).
109.   K. Y. Zhang, K. K.-S. Tso, M.-W. Louie, H.-W. Liu and K. K.-W. Lo, "A Phosphorescent Rhenium(I) Tricarbonyl Polypyridine Complex Appended with a Fructose Pendant That Exhibits Photocytotoxicity and Enhanced Uptake by Breast Cancer Cells", Organometallics, 2013, 32, 5098 – 5102 ( Link ).
108.   K. Y. Zhang and K. K.-W. Lo, Chemosensing and Diagnostics. In Coordination and Organometallic Chemistry (Volume 8) of Comprehensive Inorganic Chemistry II; V. W.-W. Yam Ed.; Elsevier: Amsterdam, 2013, pp 657 – 732 ( Link ).
107.   S. P.-Y. Li, C. T.-S. Lau, M.-W. Louie, Y.-W. Lam, S.-H. Cheng and K. K.-W. Lo, "Mitochondria-targeting Cyclometalated Iridium(III)–PEG Complexes with Tunable Photodynamic Activity", Biomaterials, 2013, 34, 7519 – 7532 ( Link ).
106.   K. K. W. Lo, W. H. T. Law, J. C. Y. Chan, H. W. Liu and K. Y. Zhang, "Photophysical and Cellular Uptake Properties of Novel Phosphorescent Cyclometallated Iridium(III) Bipyridine D-Fructose Complexes", Metallomics, 2013, 5, 808 – 812 ( Link ) (an invited paper included in the Themed Issue Metallomics in China).
105.   C. Y. S. Chung, S. P. Y. Li, M. W. Louie, K. K. W. Lo and V. W. W. Yam, "Induced Self-assembly and Disassembly of Water-soluble Alkynylplatinum(II) Terpyridyl Complexes with “Switchable” Near-infrared (NIR) Emission Modulated by Metal–Metal Interactions over Physiological pH: Demonstration of pH-responsive NIR Luminescent Probes in Cell-imaging Studies", Chemical Sciences, 2013, 4, 2453 – 2462 ( Link ).
104.   X. Chen, G. Zhu, Y. Yang, B. Wang, L. Yan, K. Y. Zhang, K. K.-W. Lo and W. Zhang, “A Diamond Nanoneedle Array for Potential High-Throughput Intracellular Delivery", Advanced Healthcare Materials, 2013, 2, 1103 – 1107 ( Link ). Cover Picture for Issue 8 ( Link ).
103.   A. W.-T. Choi, C.-S. Poon, H.-W. Liu, H.-K. Cheng and K. K.-W. Lo, “Rhenium(I) Polypyridine Complexes Functionalized with a Diaminoaromatic Moiety as Phosphorescent Sensors for Nitric Oxide", New Journal of Chemistry, 2013, 37, 1711 – 1719 ( Link ) (an invited paper included in the China Souvenir Special Issue). Cover Picture for Issue 6 ( Link ).
102.   K. K. W. Lo, B. T. N. Chan, H. W. Liu, K. Y. Zhang, S. P. Y. Li and T. S. M. Tang, “Cyclometalated Iridium(III) Polypyridine Diphenylcyclooctyne Complexes as the First Phosphorescent Bioorthogonal Probes”, Chemical Communications, 2013, 49, 4271 – 4273 ( Link ).
101.   A. W. T. Choi, M. W. Louie, S. P. Y. Li, H. W. Liu, B. T. N. Chan, T. C. Y. Lam, A. C. C. Lin, S. H. Cheng and K. K. W. Lo, “Emissive Behavior, Cytotoxic Activity, Cellular Uptake, and PEGylation Properties of New Luminescent Rhenium(I) Polypyridine Poly(ethylene glycol) Complexes”, Inorganic Chemistry, 2012, 51, 13289 – 13302 ( Link ).
100.   B. Wang, Y. Liang, H. Dong, T. Tan, B. Zhan, J. Cheng, K. K. W. Lo, Y. W. Lam and S. H. Cheng, “A Luminescent Cyclometalated Iridium(III) Complex Accumulates and Induces Mitochondrial Shortening by Conjugation to Specific Protein Targets”, ChemBioChem, 2012, 13, 2729 – 2737 ( Link ).
99.   K. K. W. Lo and S. P. Y. Li, Luminescent Transition-Metal Complexes as Biomolecular and Cellular Probes. In Molecular Design and Applications of Photofunctional Polymers and Materials; R. W.-Y. Wong, A. S. Abd-El-Aziz Eds.; RSC: Cambridge, 2012, pp 130 – 198 ( Link ).
98.   K. K. W. Lo and K. Y. Zhang, “Iridium(III) Complexes as Therapeutic and Bioimaging Reagents for Cellular Applications”, RSC Advances, 2012, 2, 12069 – 12083 ( Link ).
97.   S. P. Y. Li, T. S. M. Tang, K. S. M. Yiu and K. K. W. Lo, “Cyclometalated Iridium(III) Polyamine Complexes with Intense and Long-lived Multicolor Phosphorescence: Synthesis, Crystal Structure, Photophysical Behavior, Cellular Uptake, and Transfection Properties”, Chemistry – A European Journal, 2012, 18, 13342 – 13354 ( Link ).
96.   C. Y. S. Chung, S. P. Y. Li, M. W. Louie, K. K. W. Lo and V. W. W. Yam, "Induced Self-assembly and Disassembly of Water-soluble Alkynylplatinum(II) Terpyridyl Complexes with “Switchable” Near-infrared (NIR) Emission Modulated by Metal–Metal Interactions over Physiological pH: Demonstration of pH-responsive NIR Luminescent Probes in Cell-imaging Studies", Organometallics, 2012, 31, 5844 – 5855 ( Link ). Special Issue entitled "Organometallics in Biology and Medicine".
95.   Y. Wang, S. Li, S. V. Kershaw, F. Hetsch, A. Y. Y. Tam, G. Shan, A. S. Susha, C. C. Ko, V. W. W. Yam, K. K. W. Lo and A. L. Rogach, "Design of a Water-Soluble Hybrid Nanocomposite of CdTe Quantum Dots and an Iridium Complex for Photoinduced Charge Transfer", ChemPhysChem, 2012, 13, 2589 – 2595 ( Link ).
94.   K. K. W. Lo, A. W. T. Choi and W. H. T. Law, “Applications of Luminescent Inorganic and Organometallic Transition Metal Complexes as Biomolecular and Cellular Probes”, Dalton Transactions, 2012, 41, 6021 – 6027 ( Link ). Cover Picture for Issue 20 ( Link ).
93.   K. K. W. Lo, S. K. Leung and C. Y. Pan, “Luminescent Iridium(III) Arylbenzothiazole Complexes: Photophysics, Electrochemistry, Bioconjugation, and Cellular Uptake”, Inorganica Chimica Acta, 2011, 380, 343 – 349 ( Link ) (Young Investigator Award Issue 2011).
92.   M. W. Louie, T. T. H. Fong and K. K. W. Lo, “Luminescent Rhenium(I) Polypyridine Fluorous Complexes as Novel Trifunctional Biological Probes”, Inorganic Chemistry, 2011, 50, 9465 – 9471 ( Link ).
91.   P. K. Lee, W. H. T. Law, H. W. Liu and K. K. W. Lo, “Luminescent Cyclometalated Iridium(III) Polypyridine Di-2-picolylamine Complexes: Synthesis, Photophysics, Electrochemistry, Cation Binding, Cellular Internalization, and Cytotoxic Activity”, Inorganic Chemistry, 2011, 50, 8570 – 8579 ( Link ).
90.   K. K. W. Lo, K. Y. Zhang and S. P. Y. Li, “Recent Exploitation of Luminescent Rhenium(I) Tricarbonyl Polypyridine Complexes as Biomolecular and Cellular Probes”, European Journal of Inorganic Chemistry, 2011, 3551 – 3568 ( Link ). Cover Picture for Issue 24 ( Link ).
89.   M. W. Louie, H. W. Liu, M. H. C. Lam, Y. W. Lam and K. K. W. Lo, “Luminescent Rhenium(I) Polypyridine Complexes Appended with an a-D-Glucose Moiety as Novel Biomolecular and Cellular Probes”, Chemistry – A European Journal, 2011, 17, 8304 – 8308 ( Link ). Cover Picture for Issue 30 ( Link ). Featured in ChemViews Magazine ( Link ).
88.   S. K. Leung, H. W. Liu and K. K. W. Lo, “Functionalization of Luminescent Cyclometallated Iridium(III) Polypyridine Complexes with a Fluorous Moiety: Photophysics, Protein-binding, Bioconjugation, and Cellular Uptake Properties”, Chemical Communications, 2011, 47, 10584 – 10550 ( Link ). Cover Picture for Issue 38 ( Link ).
87.   Y. Qiao, J. Gao, Y. Qiu, L. Wu, F. Guo, K. K. W. Lo and D. Li, “Design, Synthesis, and Characterization of Piperazinedione-based Dual Protein Inhibitors for Both Farnesyltransferase and Geranylgeranyltransferase-I”, European Journal of Medicinal Chemistry, 2011, 46, 2264 – 2273 ( Link ).
86.   K. K. W. Lo, K. Y. Zhang and S. P. Y. Li, “Design of Cyclometallated Iridium(III) Polypyridine Complexes as Luminescent Biological Labels and Probes”, Pure and Applied Chemistry, 2011, 83, 823 – 840 ( Link ).
85.   P. K. Lee, H. W. Liu, S. M. Yiu, M. W. Louie and K. K. W. Lo, “Luminescent Cyclometallated Iridium(III) Bis(quinolylbenzaldehyde) Diimine Complexes — Synthesis, Photophysics, Electrochemistry, Protein Cross-linking Properties, Cytotoxicity and Cellular Uptake”, Dalton Transactions, 2011, 40, 2180 – 2189 ( Link ). Cover Picture for Issue 10, the Themed Issue entitled New Talent: Asia ( Link ).
84.   K. K. W. Lo, S. P. Y. Li and K. Y. Zhang, “Development of Luminescent Iridium(III) Polypyridine Complexes as Chemical and Biological Probes”, New Journal of Chemistry, 2011, 35, 265 – 287 ( Link ). Cover Picture for Issue 2 ( Link ).

83.   K. K. W. Lo and, A. H. H. Leung, “Luminescent Cyclometallated Iridium(III) Dipyridoquinoxaline Indole Complexes as Biological Probes”, Science in China Series B – Chemistry, 2010, 53, 2091 – 2098 ( Link ).
82.   H. W. Liu, K. Y. Zhang, W. H. T. Law and K. K. W. Lo, “Cyclometallated Iridium(III) Bipyridine Complexes Functionalised with an N-Methylamino-oxy Group as Novel Phosphorescent Labelling Reagents for Reducing Sugars”, Organometallics, 2010, 29, 3474 – 3476 ( Link ).
81.   S. P. Y. Li, H. W. Liu, K. Y. Zhang and K. K. W. Lo, “Modification of Luminescent Iridium(III) Polypyridine Complexes with Discrete Poly(ethylene glycol) (PEG) Pendants: Synthesis, Emissive Behavior, Intracellular Uptake, and PEGylation Properties”, Chemistry – A European Journal, 2010, 16, 8329 – 8339 ( Link ). Cover Picture for Issue 28 ( Link ).
80.   K. Y. Zhang, H. W. Liu, T. T. H. Fong, X. G. Chen and K. K. W. Lo, “Luminescent Dendritic Cyclometallated Iridium(III) Polypyridine Complexes: Synthesis, Emission Behavior, and Biological Properties”, Inorganic Chemistry, 2010, 49, 5432 – 5443 ( Link ).
79.   S. K. Leung, K. Y. Kwok, K. Y. Zhang and K. K. W. Lo, “Design of Luminescent Biotinylation Reagents Derived from Cyclometallated Iridium(III) and Rhodium(III) Bis(pyridylbenzaldehyde) Complexes”, Inorganic Chemistry, 2010, 49, 4984 – 4995 ( Link ).
78.   K. Y. Zhang, S. P. Y. Li, N. Zhu, I. W. S. Or, M. S. H. Cheung, Y. W. Lam and K. K. W. Lo, “Structure, Photophysical and Electrochemical Properties, Biomolecular Interactions, and Intracellular Uptake of Luminescent Cyclometallated Iridium(III) Dipyridoquinoxaline Complexes”, Inorganic Chemistry, 2010, 49, 2530 – 2540 ( Link ).
77.   K. K. W. Lo, M. W. Louie and K. Y. Zhang, “Design of Luminescent Iridium(III) and Rhenium(I) Polypyridine Complexes as In Vitro and In Vivo Ion, Molecular and Biological Probes”, Coordination Chemistry Reviews, 2010, 254, 2603 – 22622 ( Link ).
76.   K. K. W. Lo, “Exploitation of Luminescent Organometallic Rhenium(I) and Iridium(III) Complexes in Biological Studies”, Topics on Organometallic Chemistry, 2010, 29, 115 – 158 ( Link ).
75.   V. A. L. Roy, K. K. W. Lo, C. F. Chow, S. S. Y. Chui and C. S. Lee, “Alignment of Charge-transfer Complexes for Molecular Devices”, Journal of Materials Chemistry, 2010, 20, 434 – 438 ( Link ).
74.   M. W. Louie, M. H. C. Lam and K. K. W. Lo, “Luminescent Polypyridinerhenium(I) Bis-biotin Complexes as Crosslinkers for Avidin”, European Journal of Inorganic Chemistry, 2009, 53, 4265 – 4273 ( Link ).
73.   M. W. Louie, H. W. Liu, M. H. C. Lam, T. C. Lau and K. K. W. Lo, “Novel Luminescent Tricarbonylrhenium(I) Polypyridine Tyramine-Derived Dipicolylamine Complexes as Sensors for Zinc(II) and Cadmium(II) Ions”, Organometallics, 2009, 28, 4297 – 4307 ( Link ).
72.   K. Y. Zhang and K. K. W. Lo, “Synthesis, Properties, and Live-Cell Imaging Studies of Luminescent Cyclometallated Iridium(III) Polypyridine Complexes Containing Two or Three Biotin Pendants”, Inorganic Chemistry, 2009, 48, 6011 – 6025 ( Link ).
71.   J. S. Y. Lau, P. K. Lee, K. H. K. Tsang, C. H. C. Ng, Y. W. Lam, S. H. Cheng and K. K. W. Lo, “Luminescent Cyclometallated Iridium(III) Polypyridine Indole Complexes – Synthesis, Photophysics, Electrochemistry, Protein-Binding Properties, Cytotoxicity, and Cellular Uptake”, Inorganic Chemistry, 2009, 48, 708 – 719 ( Link ).
70.   M. W. K. K. W. Lo, P. K. Lee and J. S. Y. Lau, “Synthesis, Characterisation, and Properties of Luminescent Organoiridium(III) Polypyridine Complexes Appended with an Alkyl Chain and Their Interactions with Lipid Bilayers, Surfactants, and Living Cells”, Organometallics, 2008, 27, 2998 – 3006 ( Link ).
69.   K. K. W. Lo, K. Y. Zhang, S. K. Leung and M. C. Tang, “Exploitation of the Dual-emissive Properties of Cyclometallated Iridium(III)–Polypyridine Complexes in the Development of Luminescent Biological Probes”, Angewandte Chemie International Edition, 2008, 47, 2213 – 2216 ( Link ). Cover Picture for Issue 12 ( Link ).
68.   K. K. W. Lo, M. W. Louie, K. S. Sze and J. S. Y. Lau, “Rhenium(I) Polypyridine Biotin Isothiocyanate Complexes as the First Luminescent Biotinylation Reagents: Synthesis, Photophysical Properties, Biological Labelling, Cytotoxicity, and Imaging Studies”, Inorganic Chemistry, 2008, 47, 602 – 611 ( Link ).
67.   K. K. W. Lo, T. K. M. Lee, J. S. Y. Lau, W. L. Poon and S. H. Cheng, “Luminescent Biological Probes Derived from Ruthenium(II) Estradiol Polypyridine Complexes”, Inorganic Chemistry, 2008, 47, 200 – 208 ( Link ).
66.   K. K. W. Lo and J. S. Y. Lau, Design of Transition Metal Biotin Complexes as Non-Covalent Probes for Avidin" in “Coordination Chemistry Research Trends”, T. W. Cartere and K. S. Verley eds., Nova Publishers, New York, 2008, pp. 175 – 220 ( Link ).
65.   K. K. W. Lo, “Luminescent Transition Metal Complexes as Biological Labels and Probes”, Structure and Bonding, 2007, 123, 205 – 245 ( Link ).
64.   K. K. W. Lo, K. Y. Zhang, C. K. Chung and K. Y. Kwok, “Synthesis, Photophysical and Electrochemical Properties, and Protein-Binding Studies of Luminescent Cyclometallated Iridium(III) Bipyridine Estradiol Conjugates”, Chemistry – A European Journal, 2007, 13, 7110 – 7130 ( Link ).
63.   K. K. W. Lo, K. S. Sze, K. H. K. Tsang and N. Zhu, “Luminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Indole Complexes as Sensitive Probes for Indole-Binding Proteins”, Organometallics, 2007, 26, 3440 – 3447 ( Link ).
62.   K. K. W. Lo, K. H. K. Tsang, K. S. Sze, C. K. Chung, T. K. M. Lee, K. Y. Zhang, W. K. Hui, C. K. Li, J. S. Y. Lau, D. C. M. Ng and N. Zhu, “Non-Covalent Binding of Luminescent Transition Metal Polypyridine Complexes to Avidin, Indole-Binding Proteins and Estrogen Receptors”, Coordination Chemistry Reviews, 2007, 251, 2292 – 2310 ( Link ).
61.   M. Lepeltier, T. K. M. Lee, K. K. W. Lo, L. Toupet, H. Le Bozec and V. Guerchais, “Synthesis and Photophysical Properties of Bis-Cyclometallated Iridium(III)-Styryl Complexes and Their Saturated Analogues”, European Journal of Inorganic Chemistry, 2007, 2734 – 2747 ( Link ).
60.   K. K. W. Lo, and J. S. Y. Lau, “Cyclometallated Iridium(III) Diimine Bis(biotin) Complexes as the First Luminescent Biotin-Based Cross-Linkers for Avidin”, Inorganic Chemistry, 2007, 46, 700 – 709 ( Link ).
59.   K. K. W. Lo and T. K. M. Lee, “Luminescent Ruthenium(II) Amidodipyridoquinoxaline Biotin Complexes That Display Higher Avidin-induced Emission Enhancement”, Inorganica Chimica Acta, 2007, 360, 293 – 302 ( Link ).
58.   K. K. W. Lo, J. S. Y. Lau and N. Zhu, “Synthesis, Crystal Structures, Electrochemical and Protein-Binding Properties of Ferrocene–Indole Conjugates”, New Journal of Chemistry, 2006, 30, 1567 – 1575 ( Link ).
57.   K. K. W. Lo, J. S. Y. Lau, D. K. K. Lo and L. T. L. Lo, “Luminescent Cyclometallated Iridium(III) Polypyridine Complexes Containing a Thiourea Moiety: Synthesis, Characterisation, Photophysics, Electrochemistry and Anion-Binding Properties”, European Journal of Inorganic Chemistry, 2006, 4054 – 4062 ( Link ).
56.   K. K. W. Lo, W. K. Hui, C. K. Chung, K. H. K. Tsang, T. K. M. Lee, C. K. Li, J. S. Y. Lau and D. C. M. Ng, “Luminescent Transition Metal Complex Biotin Conjugates”, Coordination Chemistry Reviews, 2006, 250, 1724 – 1736 ( Link ).
55.   K. K. W. Lo, K. H. K. Tsang and N. Zhu, “Luminescent Tricarbonylrhenium(I) Polypyridine Estradiol Conjugates: Synthesis, Crystal Structure, and Photophysical, Electrochemical, and Protein-Binding Properties”, Organometallics, 2006, 25, 3220 – 3227 ( Link ).
54.   K. K. W. Lo, W. K. Hui, C. K. Chung, K. H. K. Tsang, T. K. M. Lee and D. C. M. Ng, “Luminescent Transition Metal Polypyridine Biotin Complexes”, Journal of the Chinese Chemical Society, 2006, 53, 53 – 65 ( Link ).
53.   K. K. W. Lo, T. K. M. Lee and K. Y. Zhang, “Luminescent Probes for Indole-Binding Proteins Derived from Ruthenium(II) Polypyridine Complexes”, Inorganica Chimica Acta, 2006, 359, 1845 – 1854 ( Link ).
52.   K. K. W. Lo, K. H. K. Tsang and K. S. Sze, “Utilisation of the Highly Environment-Sensitive Emission Properties of Rhenium(I) Amidodipyridoquinoxaline Biotin Complexes in the Development of Biological Probes”, Inorganic Chemistry, 2006, 45, 1714 – 1722 ( Link ).
51.   K. K. W. Lo, C. K. Chung and N. Zhu, “Nucleic Acid Intercalators and Avidin Probes Derived from Luminescent Cyclometallated Iridium(III)–Dipyridoquinoxaline and –Dipyridophenazine Complexes”, Chemistry – A European Journal, 2006, 12, 1500 – 1512 ( Link ).

50.   M. Lepeltier, H. Le Bozec, V. Guerchais, T. K. M. Lee and K. K. W. Lo, “Tris-cyclometallated Iridium(III) Styryl Complexes and Their Saturated Analogues: Direct Functionalisation of Ir(4-Me-ppy)3 and Hydrogen Transfer Process”, Organometallics, 2005, 24, 6069 – 6072 ( Link ).
49.   V. W. W. Yam and K. K. W. Lo, Luminescence Behaviour and Photochemistry of Organotransition Metal Compounds in “Encyclopedia of Inorganic Chemistry”, Second Edition, R. B. King ed., Wiley, London, 2005, pp. 2748 – 2779 ( Link ).
48.   K. K. W. Lo, C. K. Li and J. S. Y. Lau, “Luminescent Cyclometallated Iridium(III) Arylbenzothiazole Biotin Complexes”, Organometallics, 2005, 24, 4594 – 4601 ( Link ).
47.   K. K. W. Lo, K. H. K. Tsang, W. K. Hui and N. Zhu, “Synthesis, Characterization, Crystal Structure, and Electrochemical, Photophysical, and Protein-Binding Properties of Luminescent Rhenium(I) Diimine Indole Complexes”, Inorganic Chemistry, 2005, 44, 6100 – 6110 ( Link ).
46.   K. K. W. Lo, W. K. Hui, C. K. Chung, K. H. K. Tsang, D. C. M. Ng, N. Zhu and K. K. Cheung, “Biological Labelling Reagents and Probes Derived from Luminescent Transition Metal Polypyridine Complexes”, Coordination Chemistry Reviews, 2005, 249, 1434 – 1450 ( Link ).
45.   K. K. W. Lo and W. K. Hui, “Design of Rhenium(I) Polypyridine Biotin Complexes as a New Class of Luminescent Probes for Avidin”, Inorganic Chemistry, 2005, 44, 1992 – 2002 ( Link ).
44.   Q. T. Jiang, T. K. M. Lee, K. Chen, H. L. Wong, J. S. Zheng, J. P. Giesy, K. K. W. Lo, N. Yamashita and P. K. S. Lam, “Human Health Risk Assessment of Organochlorines Associated with Fish Consumption in a Coastal City in China”, Environmental Pollution, 2005, 136, 155 – 165 ( Link ).
43.   M. Lepeltier, T. K. M. Lee, K. K. W. Lo, L. Toupet, H. Le Bozec and V. Guerchais, “Synthesis, Structure, and Photophysical and Electrochemical Properties of Cyclometallated Iridium(III) Complexes with Phenylated Bipyridine Ligands”, European Journal of Inorganic Chemistry, 2005, 110 – 117 ( Link ).
42.   K. K. W. Lo and T. K. M. Lee, “Luminescent Ruthenium(II) Polypyridine Biotin Complexes: Synthesis, Characterisation, Photophysical and Electrochemical Properties, and Avidin-Binding Studies”, Inorganic Chemistry, 2004, 43, 5275 – 5282 ( Link ).
41.   K. K. W. Lo, J. S. W. Chan, L. H. Lui and C. K. Chung, “Novel Luminescent Cyclometallated Iridium(III) Diimine Complexes That Contain a Biotin Moiety”, Organometallics, 2004, 23, 3108 – 3116 ( Link ).
40.   K. K. W. Lo and K. H. K. Tsang, “Bifunctional Luminescent Rhenium(I) Complexes Containing an Extended Planar Diimine Ligand and a Biotin Moiety”, Organometallics, 2004, 23, 3062 – 3070 ( Link ).
39.   K. K. W. Lo, J. S. W. Chan, C. K. Chung, V. W. H. Tsang and N. Zhu, “Synthesis, Photophysical and Electrochemical Properties, and Biological Labelling Studies of Luminescent Cyclometallated Iridium(III) Bipyridine–aldehyde Complexes”, Inorganica Chimica Acta, 2004, 357, 3109 – 3118 ( Link ).
38.   K. K. W. Lo, J. S. Y. Lau, V. W. Y. Fong and N. Zhu, “Electrochemical, Photophysical, and Anion-Binding Properties of a Luminescent Rhenium(I) Polypyridine Anthraquinone Complex with a Thiourea Receptor”, Organometallics, 2004, 23, 1098 – 1106 ( Link ).
37.   R. Mukhopadhyay, K. K. W. Lo, L. L. Wong and H. A. O. Hill, “Oriented Immobilisation of Pseudomonas Putida Putidaredoxin at a Gold (111)-Buffer Interface: a Real Time Scanning Tunnelling Microscopy Study”, Journal of Microscopy, 2004, 213, 6 – 10 ( Link ).
36.   K. K. W. Lo, C. K. Li, K. W. Lau and N. Zhu, “Luminescent Cyclometallated Rhodium(III) Bis(pyridylbenzaldehyde) Complexes with Long-lived Excited States”, Dalton Transactions, 2003, 4682 – 4689 ( Link ).
35.   K. K. W. Lo, K. H. K. Tsang, W. K. Hui and N. Zhu, “Luminescent Rhenium(I) Diimine Indole Conjugates – Photophysical, Electrochemical and Protein-Binding Properties”, Chemical Communications, 2003, 2704 – 2705 ( Link ).
34.   K. K. W. Lo, C. K. Chung, T. K. M. Lee, L. H. Lui, K. H. K. Tsang and N. Zhu, “New Luminescent Cyclometallated Iridium(III) Diimine Complexes as Biological Labelling Reagents”, Inorganic Chemistry, 2003, 42, 6886 – 6897 ( Link ).
33.   K. K. W. Lo, C. K. Chung and N. Zhu, “Synthesis, Photophysical and Electrochemical Properties, and Biological Labelling Studies of Cyclometallated Iridium(III) Bis(pyridylbenzaldehyde) Complexes: Novel Luminescent Cross-Linkers for Biomolecules”, Chemistry – A European Journal, 2003, 9, 475 – 483 ( Link ).
32.   K. K. W. Lo, D. C. M. Ng, J. S. Y. Lau, R. S. S. Wu and P. K. S. Lam, “Derivatisation of Microcystin with a Redox-active Label for High-performance Liquid Chromatography/Electrochemical Detection”, New Journal of Chemistry, 2003, 27, 274 – 279 ( Link ).
31.   K. K. W. Lo, W. K. Hui and D. C. M. Ng, “Novel Rhenium(I) Polypyridine Biotin Complexes That Show Luminescence Enhancement and Lifetime Elongation upon Binding to Avidin”, Journal of the American Chemical Society, 2002, 124, 9344 – 9345 ( Link ).
30.   K. K. W. Lo, J. S. Y. Lau, D. C. M. Ng and N. Zhu, “Specific Labelling of Sulfhydryl-containing Biomolecules with Redox-active N-(ferrocenyl)-iodoacetamide”, Journal of Chemical Society, Dalton Transactions, 2002, 1753 – 1756 ( Link ).
29.   D. Djuricic, H. A. O. Hill, K. K. W. Lo and L. L. Wong, “A Scanning Tunnelling Microscopy (STM) Investigation of Complex Formation between Cytochrome P450cam and Putidaredoxin", Journal of Inorganic Biochemistry, 2002, 88, 362 – 367 ( Link ).
28.   R. Mukhopadhyay, L. L. Wong, K. K. W. Lo, T. Pochapsky and H. A. O. Hill, “A Molecular Level Study of Complex Formation between Putidaredoxin and Cytochrome P450 by Scanning Tunnelling Microscopy”, Physical Chemistry Chemical Physics, 2002, 4, 641 – 646 ( Link ).
27.   K. K. W. Lo, C. K. Chung, D. C. M. Ng and N. Zhu, “Syntheses, Characterisation and Photophysical Studies of Novel Biological Labelling Reagents Derived from Luminescent Iridium(III) Terpyridine Complexes”, New Journal of Chemistry, 2002, 26, 81 – 88 ( Link ).
26.   K. K. W. Lo, W. K. Hui, D. C. M. Ng and K. K. Cheung, “Synthesis, Characterisation, Photophysical Properties, and Biological Labelling Studies of a Series of Luminescent Rhenium(I) Polypyridine Maleimide Complexes”, Inorganic Chemistry, 2002, 41, 40 – 46 ( Link ).
25.   K. K.-W. Lo, D. C.-M. Ng and C.-K. Chung, “First Examples of Luminescent Cyclometallated Iridium(III) Complexes as Labelling Reagents for Biological Substrates”, Organometallics, 2001, 20, 4999 – 5001 ( Link ).
24.   K. K.-W. Lo, D. C.-M. Ng and C.-K. Chung, “First Examples of Luminescent Cyclometallated Iridium(III) Complexes as Labelling Reagents for Biological Substrates", Journal of Inorganic Biochemistry, 2001, 86, 318 ( Link ).
23.   K. K. W. Lo, D. C. M. Ng, W. K. Hui and K. K. Cheung, “Luminescent Rhenium(I) Polypyridine Complexes Containing an Isothiocyanate Moiety – Versatile Labelling Reagents for Biomolecules”, Journal of Chemical Society, Dalton Transactions, 2001, 2634 – 2640 ( Link ).

22.   J. J. Davis, D. Djuricic, K. K. W. Lo, E. N. K. Wallace, L. L. Wong and H. A. O. Hill, “A Scanning Tunnelling Study of Immobilised Cytochrome P450cam”, Faraday Discussions, 2000, 116, 15 – 22 ( Link ).
21.   V. W. W. Yam and K. K. W. Lo, Luminescent Behaviour of Polynuclear Metal Complexes of Copper(I), Silver(I) and Gold(I)" in “Molecular and Supramolecular Photochemistry”, Volume 4, V. Ramamurthy and K.S. Schanze eds., Marcel Dekker, New York, 1999, pp. 31 – 112 ( Link ).
20.   J. Nelson, J. L. Coyle, H. A. O. Hill, K. K. W. Lo and E. N. K. Wallace, “Electrochemical Studies on Average Valence Dicopper Cryptates: Evidence for a Transient Dicopper(II) Species?”, Journal of Inorganic Biochemistry, 1999, 74, 247 ( Link ).
19.   K. K. W. Lo, L. L. Wong and H. A. O. Hill, “Surface-Modified Mutants of Cytochrome P450cam: Enzymatic Properties and Electrochemistry”, FEBS Letters, 1999, 451, 342 – 346 ( Link ).
18.   V. W. W. Yam and K. K. W. Lo, “Luminescent Polynuclear d10 Metal Complexes”, Chemical Society Reviews, 1999, 323 – 334 ( Link ).
17.   V. W. W. Yam, K. K. W. Lo and K. M. C. Wong, “Luminescent Polynuclear Metal Acetylides”, Journal of Organometallic Chemistry, 1999, 578, 3 – 30 ( Link ).
16.   V. W. W. Yam and K. K. W. Lo, “Recent Advances in Utilisation of Transition Metal Complexes and Lanthanides as Diagnostic Tools”, Coordination Chemistry Reviews, 1999, 184, 157 – 240 ( Link ).
15.   V. W. W. Yam, Y. L. Pui, W. P. Li, K. K. W. Lo and K. K. Cheung, “Synthesis, Photophysics, and Electrochemistry of Copper(I) Diimine Complexes Containing Thia-, Selena-, and Tellura-Crowns. A Spectrochemical Ion Probe for Soft Metal Ions”, Journal of Chemical Society, Dalton Transactions, 1998, 3615 – 3621 ( Link ).
14.   C. R. Wang, K. K. W. Lo, W. K. M. Fung and V. W. W. Yam, “Ab Initio Molecular Orbital Studies on Luminescent Tetranuclear Copper(I) Complexes”, Chemical Physics Letters, 1998, 296, 505 – 514 ( Link ).
13.   V. W. W. Yam, K. K. W. Lo, W. K. M. Fung and C. R. Wang, “Design of Luminescent Polynuclear Copper(I) and Silver(I) Complexes with Chalcogenides and Acetylides as the Bridging Ligands”, Coordination Chemistry Reviews, 1998, 171, 17 – 41 ( Link ).
12.   V. W. W. Yam and K. K. W. Lo, “Luminescent Tetranuclear Copper(I) and Silver(I) Chalcogenides”, Comments on Inorganic Chemistry, 1997, 19, 209 – 229 ( Link ).
11.   V. W. W. Yam, K. K. W. Lo, K. K. Cheung and R. Y. C. Kong, “Deoxyribonucleic Acid Binding and Photocleavage Studies of Rhenium(I) Dipyridophenazine Complexes”, Journal of Chemical Society, Dalton Transactions, 1997, 2067 – 2072 ( Link ).
10.   V. W. W. Yam, K. K. W. Lo, C. R. Wang and K. K. Cheung, “Synthesis, Photophysics and Transient Absorption Spectroscopic Studies of Luminescent Copper(I) Chalcogenide Complexes. Crystal Structure of [Cu4(m-dtpm)4(m4-S)](PF6)2 {dtpm = Bis[bis(4-methylphenyl)phosphino]methane}”, Journal of Physical Chemistry A, 1997, 101, 4666 – 4672 ( Link ).
9.   C. R. Wang, K. K. W. Lo and V. W. W. Yam, “Molecular Orbital Studies of Luminescent Silver(I) Chalcogenido Clusters [Ag4(m-dppm)4(m4-E)]2+ (dppm = Ph2PCH2PPH2)”, Journal of Chemical Society, Dalton Transactions, 1997, 227 – 229 ( Link ).
8.   C. R. Wang, K. K. W. Lo and V. W. W. Yam, “Ab Initio Study of Luminescent Chalcogenido Silver(I) Clusters [Ag4(m-H2PCH2PH2)4(m4-E)]2+”, Chemical Physics Letters, 1996, 262, 91 – 96 ( Link ).
7.   V. W. W. Yam, K. K. W. Lo, C. R. Wang and K. K. Cheung, “The First Series of Luminescent (m4-Chalcogenido)silver(I) Clusters”, Inorganic Chemistry, 1996, 35, 5116 – 5117 ( Link ).
6.   V. W. W. Yam, K. K. W. Lo and K. K. Cheung, “A Novel Luminescent m4-Selenido-Bridged Copper(I) Tetramer”, Inorganic Chemistry, 1996, 35, 3459 – 3462 ( Link ).

5.   V. W. W. Yam, K. M. C. Wong, V. W. M. Lee, K. K. W. Lo and K. K. Cheung, “Synthesis, Photophysics, Ion-Binding Studies, and Structural Characterisation of Organometallic Rhenium(I) Crown Complexes”, Organometallics, 1995, 14, 4034 – 4036 ( Link ).
4.   V. W. W. Yam, K. K. W. Lo and K. K. Cheung, “Synthesis and Crystal Structure of a Novel Copper(I) Crown Complex: A Spectrochemical Metal Ion Probe for Alkali Metal and Alkaline Earth Metal Cations”, Inorganic Chemistry, 1995, 34, 4013 – 4014 ( Link ).
3.   V. W. W. Yam, K. K. W. Lo, K. K. Cheung and R. Y. C. Kong, “Synthesis, Photophysical Properties and DNA Binding Studies of Novel Luminescent Rhenium(I) Complexes. X-Ray Crystal Structure of [Re(dppn)(CO)3(py)](OTf)”, Journal of Chemical Society, Chemical Communications, 1995, 1191 – 1193 ( Link ).
2.   V. W. W. Yam and K. K. W. Lo, “Synthesis, Photophysical and Electrochemical Properties of Luminescent Dinuclear Copper(I) Diimines”, Journal of Chemical Society, Dalton Transactions, 1995, 499 – 500 ( Link ).
1.   V. W. W. Yam, S. W. K. Choi, K. K. W. Lo, W. F. Dung and R. Y. C. Kong, “Photolytic Cleavage of DNA by [Au3(dmmp)2]3+*”, Journal of Chemical Society, Chemical Communications, 1994, 2379 – 2380 ( Link ).


Journal Covers


Accounts of Chemical Research 2015
European Journal of Inorganic Chemistry 2022
European Journal of Inorganic Chemistry 2021
ChemPlusChem 2020
Chemical Communications 2017
New Journal of Chemistry 2013
Dalton Transactions 2012
European Journal of Inorganic Chemistry 2011
Chemistry – A European Journal 2011
Chemical Communications 2011
Dalton Transactions 2011
New Journal of Chemistry 2011
Chemistry – A European Journal 2010
Angewandte Chemie International Edition 2008
 
Professor Kenneth Kam-Wing Lo
羅錦榮教授

Chair Professor, Department of Chemistry
Director, Talent and Education Development Office

City University of Hong Kong
Tat Chee Avenue
Hong Kong, P. R. China

Tel: (852) 3442 7231
Fax: (852) 3442 0522
Email: bhkenlo@cityu.edu.hk
Website: http://staffweb1.cityu.edu.hk/bhkenlo
CityU Scholar: bit.ly/3FMtfR1

Associate Editor for  
Office Phone: +1 (202) 697-9452
E-mail: lo-office@inorg.acs.org

Researcher ID: B-1708-2015
ORCID ID: 0000-0002-2470-5916

Chair of Previous Conferences

         
 

Research Interests   


The main theme of our work is the utilization of luminescent transition metal complexes as nonisotopic covalent labels and noncovalent probes for biomolecules.

We have designed strongly luminescent rhenium(I), rhodium(III) and iridium(III) polypyridine complexes with an isothiocyanate, aldehyde, iodoacetamide and maleimide moiety.  Amine- and sulfhydryl-modified oligonucleotides, amino acids, peptides and proteins have been labelled with these complexes to yield luminescent bioconjugates.  New bioassays for molecular substrates including the drug digoxin have been developed.

Luminescent rhenium(I), ruthenium(II) and iridium(III) polypyridine complexes containing a biotin, indole, estradiol and fatty acid pendant have been designed.  All the complexes display increased emission intensities and lifetimes upon binding to their respective biological receptors. We have used a selection of these complexes with intense and long-lived emission as energy donors in FRET-based bioassays.  Additionally, systematic variation of the polypyridine ligands results in the production of new luminescent biological crosslinkers.  Furthermore, the cytotoxicity and cellular uptake properties of these complexes have been examined.




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Bioorthogonal Dissociative Rhenium(I) Photosensitisers for Controlled Immunogenic Cell Death Induction
Dual-emissive Iridium(III) Complexes as Phosphorescent Probes with Orthogonal Responses to Analyte Binding and Oxygen Quenching
A Concerted Enzymatic and Bioorthogonal Approach for Extracellular and Intracellular Activation of Environment-Sensitive Ruthenium(II)-Based Imaging Probes and Photosensitizers
Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications
Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing
Photofunctional Cyclometalated Iridium(III) Polypyridine Methylsulfone Complexes as Sulfhydryl-specific Reagents for Bioconjugation, Bioimaging and Photocytotoxic Applications
Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications
Phosphorogenic Iridium(III) <em>bis</em>-Tetrazine Complexes for Bioorthogonal Peptide Stapling, Bioimaging, Photocytotoxic Applications, and the Construction of Nanosized Hydrogels
Tuning the Organelle Specificity and Cytotoxicity of Iridium(III) Photosensitisers for Enhanced Phototheranostic Applications
Luminescent Rhenium(I) Perfluorobiphenyl Complexes as Site-specific Labels for Peptides to Afford Photofunctional Bioconjugates
Utilization of Rhenium(I) Polypyridine Complexes Featuring a Dinitrophenylsulfonamide Moiety as Biothiol-Selective Phosphorogenic Bioimaging Reagents and Photocytotoxic Agents
Luminescent Neutral Cyclometalated Iridium(III) Complexes Featuring a Cubic Polyhedral Oligomeric Silsesquioxane for Lipid Droplet Imaging and Photocytotoxic Applications
Bioorthogonal Control of the Phosphorescence and Singlet Oxygen Photosensitisation Properties of Iridium(III) Tetrazine Complexes
Photofunctional Cyclometalated Iridium(III) Polypyridine Complexes Bearing a Perfluorobiphenyl Moiety for Bioconjugation, Bioimaging, and Phototherapeutic Applications

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Last updated 31 October 2023