Classification of Core Enzymes

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Classification Short name Detection criteria
non-reducing polyketide synthase NR-PKS With: PKS_KS + PKS_AT + fPKS_PT
Without: fPKS_KR + AA-adenyl-dom
partially reducing polyketide synthase PR-PKS With: PKS_KS + PKS_AT + fPKS_TH
Without: AA-adenyl-dom
highly reducing polyketide synthase HR-PKS With: PKS_KS + PKS_AT + fPKS_DH
Without: AA-adenyl-dom
type III polyketide synthase T3PKS With: Chal_sti_synt_N or Chal_sti_synt_C
PKS-like enzyme PKS-like With: PKS_KS + PKS_AT
Without: fPKS_PT + fPKS_TH + fPKS_DH
nonribosomal peptide synthetase NRPS With: AA-adenyl-dom + (NRPS_C or NRPS_CT)
Without: PKS_KS
NRPS-like enzyme NRPS-like With: AA-adenyl-dom + (fPKS_R or Thioesterase or Abhydrolase_3 or ACP_PCP)
Without: NRPS_C + NRPS_CT + PKS_KS
polyketide synthase-nonribosomal peptide synthetase PKS-NRPS With: PKS_KS + AA-adenyl-dom
PKS_KS appears before AA-adenyl-dom
nonribosomal peptide synthetase-polyketide synthase NRPS-PKS With: PKS_KS + AA-adenyl-dom
PKS_KS appears after AA-adenyl-dom
canonical class I terpene cyclase TC (Class1) With: Terpene_syn_C_2 or Terpene_synth_C
Without: GGPS
Tri5-like terpene synthase TC (Tri5) With: TRI5
squalene-hopene cyclase/oxidosqualene cyclase TC (SHC/OSC) With: SQHop_cyclase_N or SQHop_cyclase_C
Pyr4-like terpene cyclase TC (Pyr4) With: Pyr4
UbiA-like terpene synthase TC (UbiA) With: UbiA_TC
PbcA-like terpene synthase TC (PbcA) With: PbcA
Without: GGPS
AstC-like terpene synthase TC (AstC) With: AstC
ABA3-like terpene synthase TC (ABA3) With: ABA3
AsR6-like terpene synthase TC (AsR6) With: AsR6
bifunctional prenyltransferase/terpene cyclase chimeric TS With: (Terpene_syn_C_2 or Terpene_synth_C or PbcA) + GGPS
UbiA-like prenyltransferase PT (UbiA) With: UbiA_PT
IPPS-type prenyltransferase PT (PaxC) With: PaxC
DMATS-type prenyltransferase PT (DMATS) With: Trp_DMAT
polyprenyl pyrophosphate synthase PPPS With: GGPS
Without: Terpene_syn_C_2 + Terpene_synth_C + PbcA
ribosomally synthesized and posttranslationally modified peptide (RiPP) precursor peptide RiPP PP N/A
arginine-containing cyclodipeptide synthase RCDPS With: AnkA
isocyanide synthase ICS With: DIT1_PvcA
phosphoenolpyruvate mutase PEPM With: PEP_mutase
ε-poly-L-lysine synthetase ePLS With: AA-adenyl-dom + NRPS_term_dom
Without: PKS_KS