Output

Publications at CityU

(* denotes corresponding author. † denotes equal contribution.)

  1. F. Wang, L. S. Liu, P. Li, C. H. Lau, H. M. Leung, Y R. Chin, C. Tin, P. K. Lo*. “Cellular Uptake, Tissue Penetration, Biodistribution, and Biosafety of Threose Nucleic Acids: Assessing In Vitro and In Vivo Delivery” Materials Today Bio 2022, DOI: 10.1016/j.mtbio.2022.100299.

  2. F. Wang, P. Li, H. C. Chu, P. K. Lo*. “Nucleic Acids and Their Analogues for Biomedical Applications” Biosensors 2022, 12, 93.

  3. F. Wang, L. S. Liu, P. Li, H. M. Leung, D. Y. Tam, P. K. Lo*. “Biologically Stable Threose Nucleic Acid-Based Probes for Real-Time microRNA Detection and Imaging in Living Cells” Molecular Therapy - Nucleic Acids 2022, 27, 787-796.

  4. F. Wang, X. Men, Ha. Chen, F. Mi, M. Xu, X. Men, Z. Yuan*, P. K. Lo*. “Second Near Infrared Photoactivatable Biocompatible Polymer Nanoparticles for Effective in Vitro and in Vivo Cancer Theranostics” Nanoscale, 2021, 13, 13410-13420.

  5. H. M. Leung†, C. H. Lau†, J. W. -T. Ho, M. S. Chan, T. J. H. Chang, L. H. Law, F. Wang D. Y. Tam, L. S. Liu, K. W. Y. Chan, C. Tin*, P. K. Lo*. “Targeted Brain Tumor Imaging by Using Discrete Biopolymer-Coated Nanodiamonds across the Blood Brain Barrier” Nanoscale, 2021, 13, 3184 – 3193.

  6. L. S. Liu, F. Wang, Y. Ge, P. K. Lo*. " Recent Developments in Aptasensors for Diagnostic Applications" ACS Applied Materials & Interfaces, 2021, 13, 9329–9358.

  7. D. Y. Tam†, J. W.-T Ho†, M. S. Chan, C. H. Lau, T. J. H. Chang, H. M. Leung, L. S. Liu, F. Wang, L. L. H. Chan, C. Tin*, P. K. Lo*. "Penetrating the Blood–Brain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy" ACS Applied Materials & Interfaces, 2020, 12, 28928−28940.

  8. M. S. Chan, H. M. Leung, S. W. Wong, Z. Lin, Q. Gao, T. J. H. Chang, K. W. C. Lai, P. K. Lo*. “Reversible Reconfiguration of Well-Defined High-Order DNA Nanostructures by G-Quadruplex-Mediated Assembly Approach” Nanoscale, 2020, 12, 2464-2471.

  9. Q. Gao, Z. Dai, S. Zhang, Y. Fang, K. Yung, P. K. Lo, K. W. C. Lai. “Interaction of Sp1 and APP promoter elucidates a mechanism for Pb2+ caused neurodegeneration”. Archives of Biochemistry and Biophysics, 2020, 681, 108265.

  10. L. T. Chu, H. M. Leung, P. K. Lo, T. H. Chen “Visual Detection of Lead Ions Based on Nanoparticle-Amplified Magnetophoresis and Mie Scattering” Sensors & Actuators: B. Chemical 2020, 306, 127564.

  11. F. Wang, H. Chen, Z. Liu, F. Mi, X. Fang, J. Liu, M. Wang, P. K. Lo, Q, Li. “Conjugated polymer dots for biocompatible siRNA delivery” New J. Chem., 2019, 43, 14443-14449.

  12. F. Wang, L. S. Liu, C. H. Lau, T. J. H. Chang, D. Y. Tam, H. M. Leung, C. Tin8, P. K. Lo*. “Synthetic α-L-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy” ACS Applied Materials & Interfaces 2019, 11, 38510-38518.

  13. L. Wei, H. M. Leung, Y. Tian, P. K. Lo, D. Ho. “Fully-Integrated Liquid-core Waveguide Fluorescence Lifetime Detection Microsystem for DNA Biosensing” 2019, IEEE Access, Accepted, 10.1109/ACCESS.2019.2934764.

  14. C. H. Lau, J. W. T. Ho, P. K. Lo, C. Tin. “Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa” Molecular Therapy - Nucleic Acids 2019, 16, 637-649. (IF: 5.919, ISI 15/136, 11 % Medicine, Research & Experimental)

  15. M. S. Chan†, R. Landig†, J. Choi, H. Zhou, X. Liao, M. D. Lukin, H. Park, P. K. Lo*. “Stepwise Ligand-Induced Self-Assembly for Facile Fabrication of Nanodiamond-Gold Nanoparticle Dimers via Non-Covalent Biotin-Streptavidin Interactions” Nano Lett. 2019 19, 2020-2026. (IF: 12.279, ISI 16/293, 5.4 % Materials Science, Multidisciplinary)

  16. D. Y. Tam, X. Zhuang, P. K. Lo*. “Photo-Responsive Self-Assembled DNA Nanomaterials: Design, Working Principles and Applications” Small 2019, 15, 1805481 (IF: 10.856, ISI 17/293, 5.8 % Materials Science, Multidisciplinary)

  17. Q. Gao, Z. Dai, Y. Fang, P. K. Lo, K. W. C. Lai. “Identification of Energy Landscape As an Indicator for Toxicity of Pb(II) and Cd(II)”. Applied Physics Letters 2019, 114, 013701. (IF: 3.521, ISI 31/148, 20 % Physics, Applied)

  18. C. Liu, B. Zhou, Y. Geng, D. Y. Tam, R. Feng, H. Miao, N. Xu, X. Shi, Y. You, Y. Hong, B. Z. Tang, P. K. Lo, V. Kuryavyi, G. Zhu. “A Chair-type G-quadruplex Structure Formed by a Human Telomeric Variant DNA in K+ Solution”, Chem. Sci., 2019, 10, 218–226. (IF: 9.556, ISI 16/171, 9.3 % Chemistry, Multidisciplinary)

  19. Z. Dai, H. M. Leung, Q. Gao, F. Wang, S. W. Wong, L. S. Liu, Y. J. Au, K. W. C. Lai*, P. K. Lo*. “Facile Construction of DNA Tetrahedron in Unconventional Ladder-Like Arrangements at Room Temperature”, Nanoscale Adv. 2019, 1, 1240-1248.

  20. H. M. Leung, M. S. Chan, L. S. Liu, S. W. Wong, T. W. Lo, C. H, Lau, C. Tin, P. K. Lo*. “Dual-Function, Cationic Peptide-Coated Nanodiamond Systems: Facilitating Nuclear-Targeting Delivery for Enhanced Gene Therapy Applications”, ACS Sustainable Chemistry & Engineering 2018, 6 , 9671–9681. (IF: 6.970, ISI 9/138, 6.5 % Engineering, Chemical)

  21. L. S. Liu, H. M. Leung, D. Y. Tam, T. W. Lo, S. W. Wong, P. K. Lo*. “α-L-Threose Nucleic Acids as Biocompatible Antisense Oligonucleotides for Suppressing Gene Expression in Living Cells” ACS Applied Materials & Interfaces 2018, 10, 9736-9743.

  22. Z. Dai, P. K. Lo*. “Photo-switchable patterning of gold nanoparticles along 3D DNA nanotubes” Nanoscale 2018, 10, 5431-5435.

  23. D. Y. Tam, H. M. Leung, M. S. Chan, P. K. Lo*. “G-Quadruplex-Mediated Molecular Switching of Self-Assembled 3D DNA Nanocages” ChemNanoMat 2017, 3, 750-754.

  24. G. Wu, Z. Dai, X. Tang, Z. Lin, P. K. Lo, M. Meryyappan, K. W. C. Lai. “Graphene Field-Effect Transistors for the Sensitive and Selective Detection of Escherichia Coli Using Pyrene-Tagged DNA Aptamer” Advanced Healthcare Materials, 2017, 6, 1700736.

  25. M. S. Chan, H. M. Leung, L. S. Liu, P. K. Lo*. “Cancer-Cell-Specific Mitochondria-Targeted Drug Delivery by Dual-Ligand-Functionalized Nanodiamonds Circumvents Drug Resistance” ACS Applied Materials & Interfaces 2017, 9, 11780-11789.

  26. R.Chen, J. Zhang, J. Chelora, Y. Xiong, S. Kershaw, K. F. Li, P. K. Lo, K. W. Cheah, A. L. Rogach, J. A. Zapien, C. S. Lee. “Ruthenium (II) Complex Incorporated UiO-67 Metal-Organic Frameworks Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy” ACS Applied Materials & Interfaces 2017, 9, 11780-11789.

  27. Z. Dai, H. M. Leung, P. K. Lo*. “Stimuli-Responsive Self-Assembled DNA Nanomaterials for Biomedical Applications” Small 2017, 13, 1602881.

  28. Z. Dai, Q. Gao, M. C. Cheung, H. M. Leung, T. C. K. Lau, H. F. Sleiman, K. W. C. Lai*, P. K. Lo*. “A Highly Versatile Platform Based on Geometrically Well-Defined 3D DNA Nanostructures for Selective Recognition and Positioning of Multiplex Targets” Nanoscale 2016, 8, 18291-18295.

  29. M. S. Chan, D. Y. Tam, Z. Dai, L. S. Liu, J. W. Ho, M. L. Chan, D. Xu, M. S. Wong, C. Tin*, P. K. Lo*. “Mitochondrial Delivery of Therapeutic Agents By Amphiphilic DNA Nanocarriers” Small 2016, 12, 770-781.

  30. W. Liu, L. Liang, P. K. Lo, X. J. Gou, X. H. Sun. “A Double Branched Photosensitive Prodrug:Synthesis and Characterization of Light Triggered Drug Release” Tetrahedron Lett. 2016, 57, 959-963.

  31. Z. Wang, D. Y. Tam, A. S. Susha, M. S. Chan, S. V. Kershaw, P. K. Lo, A. L. Rogach. “Aggregation-Free DNA Nanocages/Quantum Dot Complexes Based on Electrostatic Adsorption” Colloids and Surfaces A: Physicochem. Eng. Aspects 2016, 495, 62-67.

  32. D. Y. Tam, Z. Dai, M. S. Chan, L. S. Liu, M. C. Cheung, F. Bolze, C. Tin, P. K. Lo*. “A Reversible DNA Logic Gate Platform Operated by One- and Two-Photon Excitations” Angew. Chem. Int. Ed. 2016, 55, 164-168.

  33. S. Chen, L. T. Chu, P. P. Yeung, Z. Zhao, Y. Bao, M. S. Chan, P. K. Lo, T. H. Chen. “Enzyme-Free Amplification by Nano Sticky Balls for Visual Detection of ssDNA/RNA Oligonucleotides”ACS Applied Materials & Interfaces 2015, 7, 22821-22830.

  34. M. S. Chan, D. Xu, L. Guo, D. Y. Tam, L. S. Liu, Y. Chen, M. S. Wong*, P. K. Lo*. “Cyanine Fluorophore for Cellular Protection Against ROS in Stimulated Macrophages and Two-Photon ROS Detection” Org. Biomol. Chem., 2015, 13, 7307-7312.

  35. Z. Dai, D. Y. Tam, H. Xu, M. S. Chan, L. S. Liu, F, Bolze, X. H. Sun, P. K. Lo*. “Conformational Change of Self-Assembled DNA Nanotubes Induced by Two-Photon Excitation” Small 2015, 11, 4090-4096.

  36. L. Guo, M. S. Chan, D, Xu, D. Y. Tam, F. Bolze, P. K. Lo*, M. S. Wong*. “Indole-based Cyanines as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging”. ACS Chem. Bio. 2015, 10, 1171-1175.

  37. D. Y. Tam, P. K. Lo*. “Multifunctional DNA Nanomaterials for Biomedical Applications”. J. Nanomater. Vol. 2015, Article ID 765492, 21 pages, 2015.

  38. O. Sushkov, N. Chisholm, I. Lovchinsky, M. Kubo, P. K. Lo, S. D. Bennett, D. Hunger, A. Akimov, R. L. Walsworth, H. Park, M. D. Lukin. All-Optical Sensing of a Single-Molecule Electron Spin”. Nano Lett. 2014, Vol 14, Issue 11, 6443-6448.

  39. M. S. Chan, P. K. Lo*. “Nanoneedle-Assisted Delivery of Site-Selective Peptide-Functionalized DNA Nanocages for Mitochondria and Nucleus Targeting” Small 2014, 10, 1255-1260.

  40. D. Liu, C. Yi, K. Wang, C. C. Fong, Z. Wang, P. K. Lo, D. Sun, M. S. Yang. “Reorganization of Cytoskeleton and Transient Activation of Ca2+ Channels in Mesenchymal Stem Cells Cultured on Silicon Nanowire Arrays” ACS Applied Materials & Interfaces 2013, 5, 13295-13304.

  41. G. Kucsko†, P. C. Maurer†, N. Y. Yao, M. Kubo, H. J. Noh, P. K. Lo, H. Park, and M. D. Lukin. “Nanometer- Scale Thermometry in a Living Cell” Nature 2013, 500, 54-59.

  42. W. Yang, P. S. Chan, M. S. Chan, K. F. Li, P. K. Lo, N. K. Mak, K. W. Cheah, M. S. Wong. “Two-Photon Fluorescence Probes for Imaging of Mitochondria and Lysosomes” Chem. Commun. 2013, 49, 3428-3430.

  43. W. Yang, Y. Chen, M. S. Wong*, P. K. Lo*. “Reinforced Self-assembly of Donor-Acceptor π-Conjugated Molecules to DNA Templates by Dipole-Dipole Interactions Together with Complementary Hydrogen Bonding Interactions for Biomimetics. Biomacromolecules 2012, 13, 3370-3376.

  44. D. R. Glenn, H. Zhang, N. Kasthuri, R. Schalek, P. K. Lo, A. S. Trifonov, H. Park, J. W. Lichtman, R. L. Walsworth. "Correlative Light and Electron Microscopy Using Cathodoluminescence from Nanoparticles with Distinguishable Colors” Scientific Reports, 2012, 2, 865.

Publications before CityU

  1. C. K. Ho, S. Y. Poon, P. K. Lo, M. S. Wong, W. Y. Wong. “Synthesis, Characterization and Photophysical Properties of Metallopolyynes and Metallodiynes of Platinum(II) with Dibenzothiophene Derivatives”. Journal of Inorganic and Organometallic Polymers and Materials 2013, 23, 206-215.

  2. H. Yan, A. Florian, D. A. deBruijn, C. K. McLaughlin, P. K. Lo, H. F. Sleiman*. “Chiral Metal-DNA Four-Arm Junctions and Metalated Nanotubular Structures”. Angew. Chem. Int. Ed. 2011, 50, 4620-4623

  3. P. K. Lo, P. Karam, F. A. Aldaye, C. K. McLaughlin, G. Hamblin, G. Cosa, H. F. Sleiman*. “Loading and Selective Release of Cargo in DNA Nanotubes with Longitudinal Variation”. Nat. Chem. 2010, 2, 319-328.

  4. P. K. Lo, K. Metera, H. F. Sleiman*. “Self-Assembly of Three-Dimensional DNA Nanostructures and Potential Biological Applications”. Current Opinion in Chemical Biology 2010, 14, 597-607.

  5. P. K. Lo, F. Altvater, H. F. Sleiman*. “Templated Synthesis of DNA Nanotubes with Controlled, Predetermined Lengths”. J. Am. Chem. Soc. 2010, 132, 10212-10214.

  6. Y. Wen, C. K. McLaughlin, P. K. Lo, H. Yang, H. F. Sleiman*. “Stable Gold Nanoparticle Conjugation to Internal DNA Positions: Facile Generation of Discrete Gold Nanoparticle-DNA Assemblies”. Bioconjugate Chem. 2010, 21, 1413-1416.

  7. P. K. Lo, H. F. Sleiman*. “Nucleobase-Templated Polymerization: Copying the Chain Length and Polydispersity of Living Polymers into Conjugated Polymers”. J. Am. Chem. Soc. 2009, 131, 4182-4183.

  8. F. A. Aldaye, P. K. Lo, P. Karam, C. K. McLaughlin, G. Cosa, H. F. Sleiman*. “Modular Construction of DNA Nanotubes with Readily Tunable Geometry, Rigidity, and Single- or Double-Stranded Character”. Nat. Nanotech. 2009, 4, 349-352.

  9. P. K. Lo, F. A. Aldaye, H. F. Sleiman*. “Modular Construction of DNA Nanotubes of Tunable Geometry, Alternating Size, and Single- or Double-Stranded Character”. Journal of Biomolecular Structure & Dynamics 2009, 26, 801.

  10. Z. Q. Gao, P. F. Xia, P. K. Lo, B. X. Mi, H. L. Tam, M. S. Wong*, K. W. Cheah*, C. H. Chen*. “p-Doped p-Phenylenediamine-Substituted Fluorenes for Organic Electroluminescent Devices”. Organic Electronics 2009, 10, 666-673.

  11. P. K. Lo, H. F. Sleiman*. “Synthesis and Molecular Recognition of a Conjugated Polymer with DNA-Mimetic Properties”. Macromolecules 2008, 41, 5590-5603.

  12. P. K. Lo, M. S. Wong*. “Extended Calix[4]arene-Based Receptors for Molecular Recognition and Sensing”. Sensors 2008, 8, 5313-5335.

  13. P. K. Lo, K. F. Li, M. S. Wong*, K.W. Cheah*. “Synthesis and Structure-Linear and Structure-Nonlinear Optical Properties of Multi-Dipolar Zigzag Oligoaryleneethynylenes”. J. Org. Chem. 2007, 72, 6672-6629.

  14. P. K. Lo, D. Z. Chen, Q. W. Meng*, M. S. Wong*. “Highly Ordered Smectic Phases from Polar Calix[4]arene Derivatives”. Chem. Mater. 2006, 18, 3924-3930.

  15. J. Lu, P. F. Xia, P. K. Lo, Y. Tao*, M. S. Wong*. “Synthesis and Properties of Multi-Triarylamine-Substituted Carbazole-Based Dendrimers with an Oligothiophene Core for Potential Applications in Organic Solar Cells and Light-Emitting Diodes”. Chem. Mater., 2006, 18, 6194-6203.

  16. M. S. Wong, P. F. Xia, P. K. Lo, X. H. Sun, W. Y. Wong*, S. M. Shuang*. “Synthesis of Oligophenylene-Substituted Calix[4]crown-4s and Their Silver(I) Ion-Induced Nanocones Formation”. J. Org. Chem. 2006, 71, 940-946.

  17. M. S. Wong*, P. F. Xia, X. L. Zhang, P. K. Lo, Y, -K, Cheng, K. -K. Yeung, X. Guo, S. M. Shuang. “Facile Synthesis of Oligophenylene-Substituted Calix[4]arenes and Their Enhanced Binging Properties”. J. Org. Chem, 2005, 70, 2816-2819.

Patents

  1. TNA-Based Probes for miRNA Detection
    LO, P. K. P., WANG, F. & LIU, L. S., 18 Oct 2021, (Accepted/In press/Filed) Priority No. 63/256,640

  2. Methods And Compositions for Synthesis of Two-photon Cleavable Phosphoramidite Molecules for Oligonucleotide Conjugation
    LO, P. K. P., LIU, L. S. & TAM, D. Y., 10 Jun 2021, (Accepted/In press/Filed) Priority No. 17/344,920

P.K. Peggy LO @ 2022                  City University of Hong Kong       Department of Chemistry       College of Science